Description

Prescription Medical Product  |  Rx Only

Albuark 20

Human Albumin 20% IP Infusion — Premium Plasma-Derived Therapy

A high-concentration, plasma-derived human serum albumin solution indicated for the restoration of intravascular oncotic pressure and plasma protein levels in critically ill and surgically compromised patients. Manufactured to stringent IP (Indian Pharmacopoeia) standards for uncompromising safety and clinical efficacy.

20% Albumin Concentration

IP Pharmacopoeia Grade

IV Intravenous Infusion

Clinical Overview

What is Albuark 20?

Albuark 20 is a sterile, pyrogen-free solution of purified human serum albumin at a concentration of 20% w/v, derived from carefully screened donor plasma. It is classified as a colloidal plasma volume expander and plasma protein replacement agent, indicated for use across a broad spectrum of acute and chronic clinical conditions.

As the most abundant plasma protein in the human body, albumin plays a central role in maintaining colloid osmotic (oncotic) pressure, transporting endogenous and exogenous substances, and buffering blood pH. When serum albumin falls below physiologically critical thresholds — typically below 2.5 g/dL in acute settings — intravenous albumin infusion becomes a cornerstone of resuscitative and supportive therapy.

Albuark 20 is extensively utilized in Intensive Care Units (ICUs), surgical theatres, hepatology wards, burns units, and emergency departments by specialist physicians including intensivists, hepatologists, surgeons, and nephrologists.

Therapeutic Indications

Key Clinical Applications

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Hypoalbuminemia

Clinically significant hypoalbuminemia — whether from nutritional deficiency, malabsorption, or protein-losing states — requires prompt correction. Albuark 20 rapidly replenishes depleted albumin stores, restoring oncotic pressure and improving overall plasma protein balance.

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Burns & Trauma

Severe burns result in catastrophic protein loss through exudate, capillary leak, and catabolism. In the resuscitation phase of major burns (>30% TBSA), albumin infusion corrects hypoproteinaemia, supports wound healing, and reduces interstitial oedema formation.

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Hepatic Cirrhosis & Ascites

In decompensated liver cirrhosis, albumin infusion is a standard of care — particularly following large-volume paracentesis (LVP) to prevent circulatory dysfunction, in spontaneous bacterial peritonitis (SBP) to prevent hepatorenal syndrome, and in refractory ascites management.

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Perioperative Surgical Support

Major abdominal, cardiac, and orthopaedic surgeries can precipitate acute protein loss and haemodynamic instability. Albuark 20 is employed peri-operatively to maintain oncotic pressure, reduce third-space fluid shifts, and optimise tissue oxygenation during and after complex procedures.

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Hypovolaemic Shock

As a reliable intravascular volume expander, albumin 20% is used in the acute management of hypovolaemic and distributive shock states. It effectively restores circulating blood volume, improves cardiac preload, and supports mean arterial pressure in haemodynamically unstable patients.

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Nephrotic Syndrome

Nephrotic syndrome is characterised by severe urinary albumin wasting. In acute exacerbations with critical oedema or anasarca, Albuark 20 may be co-administered with diuretics to mobilise oedema fluid and temporarily correct plasma oncotic pressure.

Pharmacology

Mechanism of Action

Human albumin exerts its therapeutic effects through multiple, interrelated physiological mechanisms that are critical to haemodynamic and biochemical homeostasis.

Oncotic Pressure Restoration

Albumin is responsible for approximately 80% of the colloid osmotic pressure of plasma. The 20% formulation exerts a hyperoncotic effect — drawing interstitial fluid back into the intravascular compartment, thereby reducing oedema and restoring effective circulating volume.

Plasma Volume Expansion

Each gram of albumin retains approximately 18 ml of fluid in the vascular space. Intravenous infusion of Albuark 20 expands plasma volume by approximately 3–4 times the infused volume, providing rapid and sustained haemodynamic support.

Organ Perfusion Optimisation

By restoring adequate circulating blood volume and cardiac preload, albumin infusion improves cardiac output, enhances renal and hepatic perfusion, and helps prevent multi-organ dysfunction in critically ill patients.

Transport & Antioxidant Function

Albumin carries hormones, fatty acids, bilirubin, drugs, and metal ions. Its free thiol group (Cys-34) provides intrinsic antioxidant activity — particularly relevant in oxidative-stress conditions such as sepsis, liver failure, and critical illness.

Expert Clinical Perspective

A Note from Our Medical Team

In our critical care practice, albumin infusion remains an irreplaceable tool — not merely as a volume expander, but as a multifunctional plasma protein that restores physiological equilibrium. Albuark 20 provides the high-concentration albumin needed when rapid oncotic correction is paramount: following large-volume paracentesis in cirrhotic patients, in haemodynamically unstable sepsis, or in the acute resuscitation of major burns. The 20% formulation is particularly valuable when fluid restriction is necessary, as it delivers equivalent albumin in a smaller infusion volume compared to 4–5% preparations. Clinicians must, however, individualize dosing based on serum albumin levels, clinical context, and the underlying pathophysiology — and monitor closely for circulatory overload in at-risk populations.

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Medical Review Board Critical Care Medicine & Clinical Pharmacology

Safety & Quality Profile

Manufacturing & Safety Standards

Manufacturing Standards

• Derived from carefully screened, tested human plasma
• Manufactured under cGMP (Current Good Manufacturing Practice) conditions
• Pathogen reduction steps including pasteurization at 60°C for 10 hours
• Compliant with Indian Pharmacopoeia (IP) specifications
• Sterile, pyrogen-free, and free of preservatives

Clinical Safety Considerations

• Monitor for signs of circulatory overload (especially in cardiac/renal patients)
• Administer under medical supervision with IV access
• Vital signs and urinary output should be monitored during infusion
• Rare hypersensitivity reactions: observe during first 30 minutes
• Electrolyte status should be evaluated alongside therapy

Summary

Albuark 20 — Trusted in Critical Care

Albuark 20 (Human Albumin 20% IP Infusion) is a cornerstone plasma-derived therapy for hospitals, ICUs, and critical care centres. Its proven efficacy in managing hypoalbuminaemia, cirrhotic decompensation, major surgical procedures, and acute volume loss makes it an essential component of modern resuscitative medicine. Healthcare providers can rely on Albuark 20 for consistent quality, rigorous safety standards, and meaningful clinical outcomes for their most vulnerable patients.

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Medical Disclaimer: This content is intended for qualified healthcare professionals only and is for informational purposes. It does not constitute medical advice, replace clinical judgment, or serve as a prescribing guide. Albuark 20 is a prescription-only medicine (Rx). Always refer to the current approved prescribing information and consult relevant clinical guidelines before administration. For adverse event reporting, contact your local pharmacovigilance authority.